Upson benefits from a legacy of great leadership. Decisions made over the past 60 years have positioned our hospital to excel clinically, financially and operationally. Each of these board members is a volunteer, and each is certified by the Georgia Hospital Association.

| Norman S. Morris | 1996 | VP 2003- 2007, President 2007-Present |
| Barney Hancock | 1997 | |
| William H. Hightower, IV | 2003 | |
| James J. Edwards, Jr. | 2005 | VP 2007 - Present |
| Kay Robinson | 2006 | |
| Steve Keadle | 2007 | |
| Ralph P. Warnock, MD | 2008 |
J. B. Hardy 1947 – 1964 President 1947-1964
Julian T. Hightower 1947 – 1987 Vice-President 1947-1987
Rob Stephens 1947
S. Wayne Hempstead 1947 – 1976 President 1972 -1976
J. Curt Woodson 1947
John H. McGehee 1947 - 1953
L.A. Mallory, Jr. 1954 – 1980 President 1976 - 1980
Paul Hancock 1957 - 1974
AltonHarvey 1957 – 1972 President 1964 - 1972
Victor Thurston 1973 - 1987
Hubert Hancock 1974 – 1997 President 1980 -1997
Mike Lambert 1998 - 2000
Hugo Starling 1981 – 2007 President 1997- 2007
William C. Byrd 1987 - 2006
George H. Hightower, Sr. 1987 – 2003 Vice-President 1987- 2003
Reshann P. Adams 2003 - 2004
W. M. Oxford, M.D. 1998 – 2007
Doris Grace 1999 - 2012